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It is not known whether the inhibitory effects of colchicine on meiotic prophase events are caused by microtubule depolymerization in the highly specialized meiotic cell.

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In the case of fmf, the usefulness of colchicine in helping to control debilitating attacks of fever and abdominal pain was already established, and the orphan indication for colcrys was approved on the basis of a review of previously collected data, along with additional limited safety information from the pharmacokinetic trials.

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